striatal degeneration, autosomal dominant
Findings
No curated finding names striatal degeneration, autosomal dominant yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
An adult-onset movement disorder characterized by bradykinesia, dysarthria and muscle rigidity.
Definition from the Mondo Disease Ontology (MONDO:0000211), read 2026-09-29. CC BY 4.0.
Features
7 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormality of movementHPOHP:0100022
- Very frequent (80% to 99% of cases)
- BradykinesiaHPOHP:0002067
- Very frequent (80% to 99% of cases)
- DysarthriaHPOHP:0001260
- Very frequent (80% to 99% of cases)
- DysdiadochokinesisHPOHP:0002075
- Very frequent (80% to 99% of cases)
- RigidityHPOHP:0002063
- Very frequent (80% to 99% of cases)
- DysphagiaHPOHP:0002015
- Frequent (30% to 79% of cases)
- Gait disturbanceHPOHP:0001288
- Frequent (30% to 79% of cases)
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- PDE8BHGNC:8794
- Supportive · Orphanet · Autosomal dominant · 2021
Where it sits
- A kind of
Other names
2 names
Resolves to: striatal degeneration, autosomal dominant
- Also called
- ADSDautosomal dominant striatal neurodegeneration