spermatogenic failure 4
MONDO:0010052Mondo
Findings
No curated finding names spermatogenic failure 4 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Any azoospermia in which the cause of the disease is a mutation in the SYCP3 gene.
Definition from the Mondo Disease Ontology (MONDO:0010052), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Young adult onset
HPO, annotations 2026-09-02
Features
2 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- AzoospermiaHPOHP:0000027
- 2 of 2 reported patients · Male
- Male infertilityHPOHP:0003251
- 2 of 2 reported patients · Male
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- SYCP3HGNC:18130
- Limited · Ambry Genetics · Autosomal dominant · 2024
Where it sits
- A kind of
Other names
3 names
Resolves to: spermatogenic failure 4
- Also called
- azoospermia caused by mutation in SYCP3spermatogenic failure type 4SYCP3 azoospermia