spermatogenic failure 3
MONDO:0011720Mondo
Findings
No curated finding names spermatogenic failure 3 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Any azoospermia in which the cause of the disease is a mutation in the SLC26A8 gene.
Definition from the Mondo Disease Ontology (MONDO:0011720), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Young adult onset
HPO, annotations 2026-09-02
Features
2 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Male infertilityHPOHP:0003251
- 3 of 3 reported patients
- Reduced sperm motilityHPOHP:0012207
- 3 of 3 reported patients
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- SLC26A8HGNC:14468
- Limited · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2020
- No Known Disease Relationship · Ambry Genetics · Autosomal dominant · 2018
Where it sits
- A kind of
Other names
3 names
Resolves to: spermatogenic failure 3
- Also called
- azoospermia caused by mutation in SLC26A8SLC26A8 azoospermiaspermatogenic failure type 3