generalized pustular psoriasis
Findings
No curated finding names generalized pustular psoriasis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A rare and extreme form of psoriasis characterized by the appearance of sterile pustules which can take many patterns. All the main pathological features of the disease are accentuated. Generalized pustular psoriasis is clinically heterogeneous in its age at onset, precipitants, severity, and natural history. Many overlapping clinical entities are recognized. There is a relationship between these entities and plaque psoriasis, as some individuals may have episodes of plaque psoriasis preceding or following the generalized pustular psoriasis, but in others generalized pustular psoriasis occurs as the sole phenotype without plaque psoriasis at any time.
Definition from the Mondo Disease Ontology (MONDO:0100491), read 2026-09-29. CC BY 4.0.
Features
27 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- ArthralgiaHPOHP:0002829
- Obligate (100% of cases)
- Elevated erythrocyte sedimentation rateHPOHP:0003565
- Obligate (100% of cases)
- Erythematous plaqueHPOHP:0025474
- Obligate (100% of cases)
- PustuleHPOHP:0200039
- Obligate (100% of cases)
- Abnormal nail morphologyHPOHP:0001597
- Very frequent (80% to 99% of cases)
- ErythrodermaHPOHP:0001019
- Very frequent (80% to 99% of cases)
- PainHPO
Show the remaining 15
- Geographic tongueHPOHP:0025252
- Frequent (30% to 79% of cases)
- Increased total leukocyte countHPOHP:0001974
- Frequent (30% to 79% of cases)
- OverweightHPOHP:0025502
- Frequent (30% to 79% of cases)
- Decreased total lymphocyte countHPOHP:0001888
- Occasional (5% to 29% of cases)
- Elevated circulating hepatic transaminase concentrationHPOHP:0002910
- Occasional (5% to 29% of cases)
- HypoalbuminemiaHPOHP:0003073
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
- Narrower terms (1)