Compound

tert-butyl hydroperoxide

A direct-acting oxidative stress-inducing agent used to examine the effects of oxidant stress on Ca(2+)-dependent signal transduction in vascular endothelial cells. It is also used as a catalyst in polymerization reactions and to introduce peroxy groups into organic molecules.

Definition from MeSH (D020122), National Library of Medicine, read 2026-09-23. NLM revises MeSH; this copy may not reflect its current record.

CHEBI:64090ChEBI

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Structure

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A generated conformer of tert-butyl hydroperoxide — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound
Formula: C4H10O2
Mass: 90.122 g/mol
Charge: 0
InChIKey: CIHOLLKRGTVIJN-UHFFFAOYSA-N
SMILES: CC(C)(C)OO
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

5 entities

5 entities reached.

0 reported hops5 assembled from the scaffold

What the reference databases state

Statements

5 statements

5 statements · 1 reference database · Subject: tert-butyl hydroperoxide · Sources: Rhea

Order

tert-butyl hydroperoxide is a substrate of CLIC2ProteinRhea RHEA:69412Inferred only
tert-butyl hydroperoxide is a substrate of GPX1ProteinRhea RHEA:69412Inferred only
tert-butyl hydroperoxide is a substrate of GPX2ProteinRhea RHEA:69412Inferred only
tert-butyl hydroperoxide is a substrate of GPX3ProteinRhea RHEA:69412Inferred only
tert-butyl hydroperoxide is a substrate of GPX4ProteinRhea RHEA:69412Inferred only

Reactions

2 reactions

tert-butyl hydroperoxide+[thioredoxin]-dithioltert-butanol+[thioredoxin]-disulfide+water
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:63840CC BY 4.0Reference data
tert-butyl hydroperoxide+2glutathionetert-butanol+glutathione disulfide+water
Catalysed by CLIC2 or GPX1 or GPX2 or GPX3 or GPX4
Reaction pageLeft to rightBalanced
Rhea RHEA:69412CC BY 4.0Reference data

Other names

8 names

Resolves to: tert-butyl hydroperoxide

Also called: 1,1-Dimethylethyl hydroperoxide2-Hydroperoxy-2-methylpropaneDimethylethyl hydroperoxidet-butyl hydroperoxidet-ButylhydroperoxideTBHPtert-ButylhydroperoxideTertiary-butyl hydroperoxide