Compound
angiotensin II
An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by angiotensin converting enzyme. The amino acid in position 5 varies in different species. To block vasoconstriction and hypertension effect of angiotensin II, patients are often treated with ACE inhibitors or with angiotensin II type 1 receptor blockers.
Structure
No depiction stored
No three-dimensional record for this entry.
- Class
- Organic compound
- Formula
- C50H71N13O12
- Mass
- 1046.197 g/mol
- Charge
- 0
- InChIKey
- CZGUSIXMZVURDU-JZXHSEFVSA-N
- SMILES
- CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC(=O)[O-])C(C)C)C(=O)N[C@@H](Cc1cncn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)[O-]
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
1 entity
1 entities reached.
0 reported hops1 assembled from the scaffold
What the reference databases state
Statements
1 statement
1 statement · 1 reference database · Subject: angiotensin II · Sources: Rhea
- angiotensin II is a substrate of ACE2ProteinRhea RHEA:26554Inferred only
Reactions
2 reactions
angiotensin II+waterangiotensin-(1-7)+L-phenylalanine
Catalysed by ACE2
Reaction pageLeft to rightBalanced
Rhea RHEA:26554CC BY 4.0Reference data
angiotensin I+waterL-histidyl-L-leucine+angiotensin II
Catalysed by ACE
Reaction pageLeft to rightBalanced
Rhea RHEA:63560CC BY 4.0Reference data