Compound
angiotensin I
A decapeptide that is cleaved from precursor angiotensinogen by renin. Angiotensin I has limited biological activity. It is converted to angiotensin II, a potent vasoconstrictor, after the removal of two amino acids at the C-terminal by angiotensin converting enzyme.
Structure
No depiction stored
No three-dimensional record for this entry.
- Class
- Organic compound
- Formula
- C62H89N17O14
- Mass
- 1296.499 g/mol
- Charge
- 0
- InChIKey
- ORWYRWWVDCYOMK-HBZPZAIKSA-N
- SMILES
- CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC(=O)[O-])C(C)C)C(=O)N[C@@H](Cc1cncn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cncn1)C(=O)N[C@@H](CC(C)C)C(=O)[O-]
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
2 entities
2 entities reached.
0 reported hops2 assembled from the scaffold
What the reference databases state
Statements
2 statements
2 statements · 1 reference database · Subject: angiotensin I · Sources: Rhea
- angiotensin I is a substrate of ACEProteinRhea RHEA:63560Inferred only
- angiotensin I is a substrate of ACE2ProteinRhea RHEA:63532Inferred only
Reactions
2 reactions
angiotensin I+waterangiotensin-(1-9)+L-leucine
Catalysed by ACE2
Reaction pageLeft to rightBalanced
Rhea RHEA:63532CC BY 4.0Reference data
angiotensin I+waterL-histidyl-L-leucine+angiotensin II
Catalysed by ACE
Reaction pageLeft to rightBalanced
Rhea RHEA:63560CC BY 4.0Reference data
Other names
4 names
Resolves to: angiotensin I
- Also called
- Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-LeuL-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucine
- Systematic name
- N(5)-[amino(iminio)methyl]-N(2)-[(2S)-2-azaniumyl-3-carboxylatopropanoyl]-L-ornithyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-N-[(1S)-1-carboxylato-3-methylbutyl]-L-histidinamideN5-[amino(iminio)methyl]-N2-[(2S)-2-azaniumyl-3-carboxylatopropanoyl]-L-ornithyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-N-[(1S)-1-carboxylato-3-methylbutyl]-L-histidinamide