serum albumin

no effect

There were no significant differences in serum intact parathyroid hormone (PTH) bicarbonate, albumin or calcitriol levels between the groups after 12 weeks treatment

PMID 10383011 · one of two readings recorded this

hypercalcaemia incidence (serum calcium >= 2.8 mmol/l)

unclear, p = 0.03

The incidence of hypercalcaemia defined as a serum calcium level > or =2.8 mmol/l was significantly higher in CaAC than in CaKE treated patients (n = 8 vs. n = 1, P = 0.03)

PMID 10383011 · one of two readings recorded this

serum bicarbonate

no effect

There were no significant differences in serum intact parathyroid hormone (PTH) bicarbonate, albumin or calcitriol levels between the groups after 12 weeks treatment

PMID 10383011 · one of two readings recorded this

serum calcitriol

no effect

There were no significant differences in serum intact parathyroid hormone (PTH) bicarbonate, albumin or calcitriol levels between the groups after 12 weeks treatment

PMID 10383011 · one of two readings recorded this

serum intact parathyroid hormone

no effect

There were no significant differences in serum intact parathyroid hormone (PTH) bicarbonate, albumin or calcitriol levels between the groups after 12 weeks treatment

PMID 10383011 · one of two readings recorded this

serum phosphate

no effect

reaching a virtually stable plateau over the remaining observation time without significant differences between the groups

PMID 10383011 · one of two readings recorded this

serum phosphate

decreases, p = 0.004

Treatment with CaAC and CaKE significantly reduced s-phosphate levels after 4 weeks (CaAC 1.95+/-0.6 vs. 2.4+/-0.53 mmol/l, P = 0.004

PMID 10383011 · one of two readings recorded this

serum phosphate

decreases, p = 0.0001

after 4 weeks (CaAC 1.95+/-0.6 vs. 2.4+/-0.53 mmol/l, P = 0.004; CaKE 1.95+/-0.4 vs. 2.47+/-0.63 mmol/l, P = 0.0001)

PMID 10383011 · one of two readings recorded this

albumin

decreases

albumin decreased significantly in the enriched group compared with the standard nutrition

PMID 12297206 · one of two readings recorded this

clinical outcome

no effect

There were no significant differences in nitrogen balance, excretion of 3-methylhistidine, or clinical outcome between groups

PMID 12297206 · one of two readings recorded this

nitrogen balance and urinary 3-methylhistidine excretion (muscle catabolism)

no effect

Not recorded as a finding: no_outcome_node: no node for nitrogen balance or 3-methylhistidine excretion

There were no significant differences in nitrogen balance, excretion of 3-methylhistidine, or clinical outcome between groups.

PMID 12297206 · one of two readings recorded this

nitrogen balance, daily urine nitrogen

no effect

Not recorded as a finding: no outcome node for nitrogen balance

There were no significant differences in nitrogen balance, excretion of 3-methylhistidine, or clinical outcome between groups.

PMID 12297206 · one of two readings recorded this

nitrogen balance

no effect

There were no significant differences in nitrogen balance, excretion of 3-methylhistidine, or clinical outcome between groups

PMID 12297206 · one of two readings recorded this

nitrogen delivery achieved

the nitrogen delivery reached only 0.10 g of nitrogen per kilogram of body weight

PMID 12297206 · one of two readings recorded this

transthyretin

decreases

Transthyretin decreased by 25% in both groups

PMID 12297206 · one of two readings recorded this

urinary 3-methylhistidine excretion, muscle catabolism

no effect

Not recorded as a finding: no outcome node for 3-methylhistidine excretion

There were no significant differences in nitrogen balance, excretion of 3-methylhistidine, or clinical outcome between groups.

PMID 12297206 · one of two readings recorded this

urinary excretion of 3-methylhistidine

no effect

There were no significant differences in nitrogen balance, excretion of 3-methylhistidine, or clinical outcome between groups

PMID 12297206 · one of two readings recorded this

lumbar spine bone mineral density (BMD), difference between treatment groups

no effect

the difference between treatment groups was estimated as 0.9% (non-significant)

PMID 17896582 · one of two readings recorded this

lumbar spine bone mineral density (BMD)

increases

The BMD of the AKG-Ca group increased by 1.6% from baseline

PMID 17896582 · one of two readings recorded this

serum CTX (C-terminal cross-linked telopeptide of type I collagen), maximum decrease of mean

decreases, p = 0.006

The maximum decrease of the mean CTX level in the AKG-Ca group was observed after 24 weeks (37.0%, p = 0.006)

PMID 17896582 · one of two readings recorded this

serum CTX, difference between study groups

decreases

The differences in CTX between study groups were statistically significant after 12 and 24 weeks

PMID 17896582 · one of two readings recorded this

serum osteocalcin (OC)

no effect

The OC serum level was not affected by treatments

PMID 17896582 · one of two readings recorded this

blood creatine kinase MB and troponin T at 4 h after aortic cross-clamp release

decreases, CK-MB median 49 [37-60] versus 32 [27-37] micrograms/L

Not recorded as a finding: a node exists but the paper states a different instrument or population

alpha-ketoglutarate reduced the appearance in blood of the ischaemic markers creatine kinase MB and troponin T (at 4 h after release of aortic cross-clamp; median [95% CI] 49 [37-60] micrograms/L in controls vs 32 [27-37] micrograms/L for creatine kinase MB, 2.0 [1.2-2.8] vs 1.1 [0.8-1.4] micrograms/L for troponin T).

PMID 7776775 · one of two readings recorded this

blood creatine kinase MB and troponin T at 4 h after release of aortic cross-clamp

decreases, creatine kinase MB median 49 [37-60] micrograms/L in controls vs 32 [27-37]; troponin T 2.0 [1.2-2.8] vs 1.1 [0.8-1.4]

Not recorded as a finding: this platform holds no node for the endpoint

alpha-ketoglutarate reduced the appearance in blood of the ischaemic markers creatine kinase MB and troponin T (at 4 h after release of aortic cross-clamp; median [95% CI] 49 [37-60] micrograms/L in controls vs 32 [27-37] micrograms/L for creatine kinase MB, 2.0 [1.2-2.8] vs 1.1 [0.8-1.4] micrograms/L for troponin T).

PMID 7776775 · one of two readings recorded this

creatine kinase MB

decreases

at 4 h after release of aortic cross-clamp; median [95% CI] 49 [37-60] micrograms/L in controls vs 32 [27-37] micrograms/L for creatine kinase MB, 2.0 [1.2-2.8] vs 1.1 [0.8-1.4] micrograms/L for troponin T

PMID 7776775 · one of two readings recorded this

troponin T

decreases

at 4 h after release of aortic cross-clamp; median [95% CI] 49 [37-60] micrograms/L in controls vs 32 [27-37] micrograms/L for creatine kinase MB, 2.0 [1.2-2.8] vs 1.1 [0.8-1.4] micrograms/L for troponin T

PMID 7776775 · one of two readings recorded this

urea

decreases

Furthermore, concentrations in plasma of proline and histidine, precursors of glutamate biosynthesis, are increased; inorganic phosphate and urea are significantly decreased in hemodialysis patients after 1 year of calcium alpha-ketoglutarate administration

PMID 8676801 · one of two readings recorded this

inorganic phosphate

decreases

Furthermore, concentrations in plasma of proline and histidine, precursors of glutamate biosynthesis, are increased; inorganic phosphate and urea are significantly decreased in hemodialysis patients after 1 year of calcium alpha-ketoglutarate administration

PMID 8676801 · one of two readings recorded this

plasma histidine

increases

Furthermore, concentrations in plasma of proline and histidine, precursors of glutamate biosynthesis, are increased; inorganic phosphate and urea are significantly decreased in hemodialysis patients after 1 year of calcium alpha-ketoglutarate administration

PMID 8676801 · one of two readings recorded this

plasma L-arginine concentration before and after 1 year of calcium alpha-ketoglutarate in malnourished haemodialysis patients (healthy group given as reference level only); also plasma proline, histidine, inorganic phosphate, urea

increases, 53.6 +/- 18.3 to 71.1 +/- 15.9 mumol/l, n = 24

Not recorded as a finding: the result compares a group with itself, not with a control

Calcium alpha-ketoglutarate administration to 24 malnourished hemodialysis patients for 1 year leads to a significant increase in plasma concentrations of L-arginine from 53.6 +/- 18.3 (compared to a healthy control group: 87.5 +/- 27.3) to 71.1 +/- 15.9 mumol/l (p < 0.05).

PMID 8676801 · one of two readings recorded this

plasma L-arginine concentration in 24 malnourished haemodialysis patients before and after 1 year of calcium alpha-ketoglutarate; also plasma proline, histidine, inorganic phosphate and urea

increases, from 53.6 +/- 18.3 to 71.1 +/- 15.9 mumol/l, before versus after 1 year, no randomised comparator arm, n = 24

Not recorded as a finding: the result compares a group with itself, not with a control

Calcium alpha-ketoglutarate administration to 24 malnourished hemodialysis patients for 1 year leads to a significant increase in plasma concentrations of L-arginine from 53.6 +/- 18.3 (compared to a healthy control group: 87.5 +/- 27.3) to 71.1 +/- 15.9 mumol/l (p < 0.05).

PMID 8676801 · one of two readings recorded this

plasma L-arginine

to 24 malnourished hemodialysis patients for 1 year leads to a significant increase in plasma concentrations of L-arginine from 53.6 +/- 18.3 (compared to a healthy control group: 87.5 +/- 27.3) to 71.1 +/- 15.9 mumol/l (p < 0.05)

PMID 8676801 · one of two readings recorded this

plasma L-arginine

increases, p = 0.05, n = 24

to 24 malnourished hemodialysis patients for 1 year leads to a significant increase in plasma concentrations of L-arginine from 53.6 +/- 18.3 (compared to a healthy control group: 87.5 +/- 27.3) to 71.1 +/- 15.9 mumol/l (p < 0.05)

PMID 8676801 · one of two readings recorded this

plasma proline

increases

Furthermore, concentrations in plasma of proline and histidine, precursors of glutamate biosynthesis, are increased; inorganic phosphate and urea are significantly decreased in hemodialysis patients after 1 year of calcium alpha-ketoglutarate administration

PMID 8676801 · one of two readings recorded this

intact parathyroid hormone (iPTH), serum phosphate, serum calcium and Ca/P ratio in haemodialysis patients on 36 months of calcium-alpha-ketoglutarate

iPTH 29 +/- 5 to 8 +/- 2 pmol/l, prestudy to end of study, no control arm

Not recorded as a finding: the result compares a group with itself, not with a control

Intact parathyroid hormone (iPTH) continuously normalized in all patients from 29 +/- 5 to 8 +/- 2 pmol/l (p < 0.001).

PMID 8676818 · one of two readings recorded this

intact parathyroid hormone (iPTH)

decreases, p = 0.001

Intact parathyroid hormone (iPTH) continuously normalized in all patients from 29 +/- 5 to 8 +/- 2 pmol/l (p < 0.001)

PMID 8676818 · one of two readings recorded this

serum Ca/P ratio

increases, p = 0.001

Ca/P ratio in serum converted significantly from 0.91 +/- 0.02 (prestudy) to 1.28 +/- 0.01 (p < 0.001)

PMID 8676818 · one of two readings recorded this

serum calcium (Ca)

increases, p = 0.05

whereas serum Ca increased from 2.2 +/- 0.1 to 2.47 +/- 0.08 mmol/l (p < 0.05)

PMID 8676818 · one of two readings recorded this

serum phosphate (P)

decreases, p = 0.001

Serum P continuously dropped from prestudy 2.6 +/- 0.1 (mean +/- SEM) to 1.9 +/- 0.07 mmol/l (p < 0.001)

PMID 8676818 · one of two readings recorded this

serum phosphate, serum calcium, Ca/P ratio and intact parathyroid hormone in haemodialysis patients on 36 months of calcium-alpha-ketoglutarate, uncontrolled before-after

decreases, iPTH 29 +/- 5 to 8 +/- 2 pmol/l

Not recorded as a finding: this platform holds no node for the endpoint

Intact parathyroid hormone (iPTH) continuously normalized in all patients from 29 +/- 5 to 8 +/- 2 pmol/l (p < 0.001).

PMID 8676818 · one of two readings recorded this

myocardial lactate release ceased

decreases, p = 0.016

Myocardial lactate release had ceased after 30 minutes of reperfusion in nearly half the alpha-KG-treated patients (6 of 13) but remained in all the control patients (11 of 11, p = 0.016)

PMID 9205160 · one of two readings recorded this

myocardial oxygen extraction

increases, p = 0.01

Myocardial oxygen extraction was higher during alpha-KG cardioplegia (p < 0.01)

PMID 9205160 · one of two readings recorded this

myocardial uptake or release of substrates and amino acids

no effect

there were no significant differences in myocardial uptake or release of substrates or amino acids

PMID 9205160 · one of two readings recorded this

other measures after reperfusion

no effect

There were no other differences after 30 minutes of reperfusion

PMID 9205160 · one of two readings recorded this

plasma creatine kinase isoenzyme MB and troponin T after heart operation, myocardial oxygen and substrate extraction

decreases

Not recorded as a finding: a node exists but the paper states a different instrument or population

alpha-Ketoglutarate treatment was associated with lower creatine kinase isoenzyme MB (F = 39.6, df = 1.172, p < 0.001) and lower troponin (F = 12.9, df = 1.172, p < 0.001).

PMID 9205160 · one of two readings recorded this

plasma creatine kinase isoenzyme MB and troponin T after heart operations; myocardial oxygen extraction; myocardial lactate release

decreases, F = 39.6 (CK-MB), F = 12.9 (troponin), df = 1.172

Not recorded as a finding: this platform holds no node for the endpoint

alpha-Ketoglutarate treatment was associated with lower creatine kinase isoenzyme MB (F = 39.6, df = 1.172, p < 0.001) and lower troponin (F = 12.9, df = 1.172, p < 0.001).

PMID 9205160 · one of two readings recorded this

plasma creatine kinase isoenzyme MB

decreases, p = 0.001

alpha-Ketoglutarate treatment was associated with lower creatine kinase isoenzyme MB (F = 39.6, df = 1.172, p < 0.001)

PMID 9205160 · one of two readings recorded this

plasma creatine kinase isoenzyme MB

decreases

The values at 4 hours were 31 +/- 2.4 microg/L versus 49 +/- 4.9 microg/L (creatine kinase isoenzyme MB) and 1.1 +/- 0.05 microg/L versus 2.0 +/- 0.34 microg/L (troponin T)

PMID 9205160 · one of two readings recorded this

plasma troponin T

decreases, p = 0.001

lower troponin (F = 12.9, df = 1.172, p < 0.001)

PMID 9205160 · one of two readings recorded this

plasma troponin T

decreases

The values at 4 hours were 31 +/- 2.4 microg/L versus 49 +/- 4.9 microg/L (creatine kinase isoenzyme MB) and 1.1 +/- 0.05 microg/L versus 2.0 +/- 0.34 microg/L (troponin T)

PMID 9205160 · one of two readings recorded this

daily cost of therapy (Denmark)

unclear

the cost of the therapy in Denmark was 10 times higher for calcium ketoglutarate compared with calcium carbonate (US$6.00/d v US$0.65/d)

PMID 9469496 · one of two readings recorded this

patients completing both treatment arms

n = 10

Of the 19 patients included, 10 completed both treatment arms

PMID 9469496 · one of two readings recorded this

plasma intact parathyroid hormone

no effect

whereas the mean plasma phosphate (4.5+/-0.3 mg/dL v 5.1+/-0.1 mg/dL) and PTH levels (266+/-125 pg/mL v 301+/-148 pg/mL) did not differ significantly between the two treatment arms

PMID 9469496 · one of two readings recorded this

plasma ionized calcium

decreases, p = 0.004

After 12 weeks of therapy, the mean (+/-SEM) plasma ionized calcium level was significantly lower in the ketoglutarate arm compared with the calcium carbonate arm (4.8+/-0.1 mg/dL v 5.2+/-0.1 mg/dL; P = 0.004)

PMID 9469496 · one of two readings recorded this

plasma phosphate

no effect

whereas the mean plasma phosphate (4.5+/-0.3 mg/dL v 5.1+/-0.1 mg/dL) and PTH levels (266+/-125 pg/mL v 301+/-148 pg/mL) did not differ significantly between the two treatment arms

PMID 9469496 · one of two readings recorded this

requirement for supplemental aluminum-aminoacetate

unclear

Supplemental aluminum-aminoacetate was not required during calcium ketoglutarate treatment, while two patients needed this supplement when treated with calcium carbonate

PMID 9469496 · one of two readings recorded this

filtration fraction

decreases, p = 0.01

Filtration fraction was lower (12.3% +/- 0.05% versus 17.2% +/- 1.1%, p < 0.01)

PMID 9527195 · one of two readings recorded this

glomerular filtration rate

no effect

which prevented a significant difference in glomerular filtration rate

PMID 9527195 · one of two readings recorded this

renal arteriovenous difference of glutamate

modulates

The renal arteriovenous differences of lactate, glutamate, glutamine, and glycine changed toward a net release during alpha-KG infusion

PMID 9527195 · one of two readings recorded this

renal arteriovenous difference of glutamine

modulates

The renal arteriovenous differences of lactate, glutamate, glutamine, and glycine changed toward a net release during alpha-KG infusion

PMID 9527195 · one of two readings recorded this

renal arteriovenous difference of glycine

modulates

The renal arteriovenous differences of lactate, glutamate, glutamine, and glycine changed toward a net release during alpha-KG infusion

PMID 9527195 · one of two readings recorded this

renal arteriovenous difference of lactate

modulates

The renal arteriovenous differences of lactate, glutamate, glutamine, and glycine changed toward a net release during alpha-KG infusion

PMID 9527195 · one of two readings recorded this

renal blood flow as percent of preoperative value; filtration fraction; glomerular filtration rate; renal arteriovenous differences of lactate, glutamate, glutamine and glycine

increases, 297% +/- 97% versus 125% +/- 20% of preoperative value

Not recorded as a finding: this platform holds no node for the endpoint

Renal blood flow was higher during alpha-KG infusion, 297% +/- 97% (of preoperative value), than in controls, 125% +/- 20% (p < 0.05).

PMID 9527195 · one of two readings recorded this

renal blood flow (percent of preoperative value), filtration fraction, glomerular filtration rate, renal arteriovenous differences of lactate, glutamate, glutamine and glycine

increases, 297% +/- 97% of preoperative value versus 125% +/- 20% in controls

Not recorded as a finding: this platform holds no node for the endpoint

Renal blood flow was higher during alpha-KG infusion, 297% +/- 97% (of preoperative value), than in controls, 125% +/- 20% (p < 0.05).

PMID 9527195 · one of two readings recorded this

renal blood flow

increases, p = 0.05

Renal blood flow was higher during alpha-KG infusion, 297% +/- 97% (of preoperative value), than in controls, 125% +/- 20% (p < 0.05)

PMID 9527195 · one of two readings recorded this