html[data-identity='g1'] .g1-header .g1-header-wide .g1-header-layers button { display: none; } html[data-identity='g1'] .g1-header-wide .g1-header-layers a { align-self: center; } html[data-identity='g1'] .g1-header .g1-header-narrow { display: none; } html[data-identity='g1'] .g1-header-nojs { display: none; } @media (width < 721px) { html[data-identity='g1'] .g1-header .g1-header-nojs { display: flex; flex-wrap: wrap; column-gap: 20px; padding: 0 16px 8px; } html[data-identity='g1'] .g1-header-nojs ul { display: flex; gap: 20px; list-style: none; margin: 0; padding: 0; box-shadow: none; } html[data-identity='g1'] .g1-header-nojs a { display: block; padding: 6px 0; font-size: 15px; line-height: 24px; color: var(--ink2); text-decoration: none; } html[data-identity='g1'] .g1-header-nojs a[aria-current='true'] { color: var(--ink); text-decoration: underline 2px var(--ember); text-underline-offset: 6px; } }

PapersPMID:582737

[Influence of 2-dimethylaminoethanol on the hepatotoxicity of paracetamol in rats and mice (author's transl)].

Arzneimittel-Forschung1979The record ↗

findings: 2
compound: 1
endpoints: 2

N,N-dimethylethanolamine

lowersAlanine aminotransferase
lowersAspartate aminotransferase

Study, every finding: animal · not in humans
Dose studied, every finding: 0.1-0.5 g/kg
Population, every finding: Rats and mice with paracetamol-induced liver injury; findings in rodents, not humans

What moved

How to read these marks →

“2-Dimethylaminoethanol (DMAE; 0.1--0.5 g/kg) significantly reduced the paracetamol-induced increments of serum-enzyme activities (GOT, GPT, SDH) in rats and mice.”
- Decreases alanine aminotransferase
  insufficient
- Decreases aspartate aminotransferase
  insufficient

Study record

Design: animal study, in vivo
Species: animal
Population: rats and mice given paracetamol
Participants: not reported
Comparator: no treatment / not stated in the paper
Duration: not reported
Endpoints measured: 7