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PapersPMID:42943002

Melatonin and Female Fertility: A Systematic Review and Meta-Analysis of Clinical Supplementation, In Vitro Experiments, and Observational Evidence.

Nutrients2026The record ↗

  1. Finding, moderate evidenceraisesClinical pregnancy rate

What moved

1 findingHow to read these marks →
  • Increases clinical pregnancy rate

    moderate

    “Among women undergoing ART, melatonin supplementation increased the clinical pregnancy rate (RR = 1.55, 95% CI: 1.23–1.94), biochemical pregnancy rate (RR = 1.61, 95% CI: 1.09–2.38) and live birth (RR = 1.59, 95% CI: 1.01–2.51).”
    Study
    meta-analysis
    Effect
    1.55 risk ratio, 95% CI 1.23 to 1.94
    Dose studied
    3 or 4 mg/day group selected for the primary analysis where several doses were given
    Population
    women undergoing assisted reproductive technology; pooled randomized and non-randomized intervention studies, 3 or 4 mg/day melatonin group selected where several doses were given

Study record

Design
meta-analysis
Species
human / mixed
Population
Women undergoing ART, women with PCOS, DOR, POF or POI, and human oocytes and embryos exposed to melatonin in vitro
Participants
not reported
Comparator
not stated in the paper
Duration
not reported
Endpoints measured
21