Papers/PMID:42862085
Long-Term Neurodevelopmental Outcome Following Three Randomized Controlled Trials of Choline in Fetal Alcohol Spectrum Disorder (FASD).
Alcohol, clinical & experimental research2026The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
choline — increases working memory performance
Evidence strength: moderate.Finding“The Working Memory Index was significantly higher for the choline group compared to placebo, F(1, 49) = 6.213, p = 0.016, with a medium effect size (Cohen's d = 0.687) and 11.3% of the variance explained.”
Quoted verbatim from Long-Term Neurodevelopmental Outcome Following Three Randomized Controlled Trials of Choline in Fetal Alcohol Spectrum Disorder (FASD).. - Study
- RCT
- Duration
- 9 months
- Dose
- 500 mg daily (1.25 g choline bitartrate) in RCT1 and RCT2; 19 mg/kg daily (290 to 500 mg) in RCT3; once daily for 9 months
- Population
- Children with fetal alcohol spectrum disorder (enrolled at 2.5-5.9 years in one of three RCTs), assessed once at about 9 years of age, 5 years after completing 9 months of choline or placebo; Stanford-Binet 5 Working Memory Index
Long-Term Neurodevelopmental Outcome Following Three Randomized Controlled Trials of Choline in Fetal Alcohol Spectrum Disorder (FASD).2026PMID:4286208510.1111/acer.70394Permalink