Papers/PMID:42410839
The effect of zolpidem on sleep efficiency and obstructive sleep apnea severity in OSA patients: A systematic review and meta‑analysis.
Medicine2026The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
zolpidem — increases total sleep time
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Meta-analysis of data from 4 studies showed that zolpidem increased total sleep time compared to placebo or no drug (MD: 0.78, 95% CI: 0.19–1.37, P =.009, I2 = 38%; Fig. 4).”
Quoted verbatim from The effect of zolpidem on sleep efficiency and obstructive sleep apnea severity in OSA patients: A systematic review and meta‑analysis.. - Study
- meta-analysis
- Dose
- 10 mg, 1 to 14 days
- Population
- Adults with obstructive sleep apnea (AHI > 5 to > 30 events/h) in 4 pooled controlled trials of zolpidem 10 mg versus placebo or no drug; one pooled trial had all participants on CPAP, one gave atomoxetine-oxybutynin in both arms
Effect 0.78 mean difference, 95% CI 0.19 to 1.37
The effect of zolpidem on sleep efficiency and obstructive sleep apnea severity in OSA patients: A systematic review and meta‑analysis.2026PMID:42410839Permalink