Papers/PMID:42314769
Gut microbiota-generated trimethylamine N-oxide from dietary choline and glucose homeostasis in humans.
American journal of physiology. Endocrinology and metabolism2026The record
2 findings · 1 compound · 2 endpoints · 2 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
2 findings
choline — no detected effect on matsuda insulin sensitivity index
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.FindingNull result“There were no statistically significant differences in insulin sensitivity (Matsuda index) or insulin resistance (HOMA-IR) between the interventions in both the acute study and short-term study.”
Quoted verbatim from Gut microbiota-generated trimethylamine N-oxide from dietary choline and glucose homeostasis in humans.. - Study
- crossover
- Dose
- 1,000 mg/day choline bitartrate vs placebo (maltodextrin)
- Population
- Healthy, sedentary adults in two randomized, double-blind, placebo-controlled crossover studies (acute and 4-week), oral glucose tolerance test
Gut microbiota-generated trimethylamine N-oxide from dietary choline and glucose homeostasis in humans.2026PMID:42314769Permalink
choline — no detected effect on HOMA-IR
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.FindingNull result“There were no statistically significant differences in insulin sensitivity (Matsuda index) or insulin resistance (HOMA-IR) between the interventions in both the acute study and short-term study.”
Quoted verbatim from Gut microbiota-generated trimethylamine N-oxide from dietary choline and glucose homeostasis in humans.. - Study
- crossover
- Dose
- 1,000 mg/day choline bitartrate vs placebo (maltodextrin)
- Population
- Healthy, sedentary adults in two randomized, double-blind, placebo-controlled crossover studies (acute and 4-week), oral glucose tolerance test
Gut microbiota-generated trimethylamine N-oxide from dietary choline and glucose homeostasis in humans.2026PMID:42314769Permalink