PapersPMID:42142423
Vascular effects of l-citrulline supplementation in healthy adults are largely influenced by the prehypertensive range of blood pressure: A double-blind, randomized, placebo-controlled, parallel-group study.
- 01 · finding
- 1
- 02 · compound
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- 03 · endpoint
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- 04 · null
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What it reported
How to read these marksWhat moved
1 finding
L-citrulline — increases flow-mediated dilation
Evidence strength: very limited.Findingreplicated ×3“L-citrulline significantly improved FMD (L-citrulline 4.66 ± 0.45%; placebo 3.46 ± 0.37%, p = .045) at week 12 in participants with high-normal blood pressure at baseline.”
Quoted verbatim from Vascular effects of l-citrulline supplementation in healthy adults are largely influenced by the prehypertensive range of blood pressure: A double-blind, randomized, placebo-controlled, parallel-group study.. - Study
- RCT
- Duration
- 3 months
- Dose
- 3000 mg L-citrulline, 12 weeks
- Population
- adults with high-normal blood pressure at baseline (subgroup); 12-week supplementation
Vascular effects of l-citrulline supplementation in healthy adults are largely influenced by the prehypertensive range of blood pressure: A double-blind, randomized, placebo-controlled, parallel-group study.2026PMID:4214242310.1016/j.nutres.2026.04.008Permalink