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PapersPMID:41780731

Independent effects of whey protein and alkali supplementation on muscle health in healthy older adults: factorial randomized controlled trial.

The American journal of clinical nutrition2026The record ↗

  1. Finding, very limited evidenceraisesSerum insulin-like growth factor 1 (IGF-1)

What moved

1 findingHow to read these marks →
  • Increases serum insulin-like growth factor 1 (IGF-1)

    very limited

    “However, 24-wk mean IGF-1 level was higher in the WP and KHCO3 groups compared with their respective placebo [WP to placebo-WP difference 14.2 ng/mL (95% CI: 7.5, 21.0; P < 0.01); KHCO3 to placebo-KHCO3 difference 7.2 ng/mL (95% CI: 0.4, 13.9; P = 0.04)].”
    Study
    RCT
    Duration
    6 months
    Effect
    7.2 mean difference, 95% CI 0.4 to 13.9
    Dose studied
    potassium bicarbonate (KHCO3) 81 mmol/d
    Population
    Healthy free-living adults aged 65 years or older in a 2 x 2 factorial trial; KHCO3 versus placebo-KHCO3 compared at the margins, with whey protein given in half of each KHCO3 comparison arm

Study record

Design
randomised controlled trial
Species
human
Population
Healthy free-living older adults aged >=65 years; 2 x 2 factorial of whey protein (form not stated in abstract) and potassium bicarbonate (abstract only, no full text)
Participants
128
Comparator
placebo
Duration
168 days
Endpoints measured
6
Declined
the paper never states the instrument the node requires