Skip to content
Catalyst

potassium hydrogencarbonateFinding

Potassium hydrogencarbonate increases serum insulin-like growth factor 1 (IGF‑1)

raisesVery limited evidenceFinding

01 · The sentence it was drawn from

“However, 24-wk mean IGF-1 level was higher in the WP and KHCO3 groups compared with their respective placebo [WP to placebo-WP difference 14.2 ng/mL (95% CI: 7.5, 21.0; P < 0.01); KHCO3 to placebo-KHCO3 difference 7.2 ng/mL (95% CI: 0.4, 13.9; P = 0.04)].”
Quoted verbatim from Independent effects of whey protein and alkali supplementation on muscle health in healthy older adults: factorial randomized controlled trial.
This finding among the 2 findings on its endpoint

potassium hydrogencarbonate

Serum insulin-like growth factor 1 (IGF-1)

raises

Effect as reported

7.2mean difference

CI 0.4 to 13.9

Who
Healthy free-living adults aged 65 years or older in a 2 x 2 factorial trial; KHCO3 versus placebo-KHCO3 compared at the margins, with whey protein given in half of each KHCO3 comparison arm
Dose studied
potassium bicarbonate (KHCO3) 81 mmol/d

Very limited evidencePMID 41780731 · 2026

02 · The study

Study
RCT
Duration
6 months

Evidence, by strength

  • strong
  • moderate
  • limited
  • very limitedthis finding
  • insufficient

03 · The paper

The American journal of clinical nutrition
What else it reported1 finding · 1 compound · 1 endpoint

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M721G7WBTCARJZGR54H1F2AC