PapersPMID:41228527
Hepatoprotective Activity of the Fruits of Eleutherococcus senticosus in Acetaminophen-Induced Liver Injury in Mice and Their Chemical Composition.
What moved
1 findingHow to read these marks →- Decreases serum creatinine concentration
very limited
“Interestingly, the ES extract supplementation mitigated this increase–creatinine was lower at both doses than with paracetamol alone, with the effect at the 750 mg/kg dose (with levels similar to the control group) and slightly weaker at the 1500 mg/kg dose.”
- Study
- animal · not in humans
- Duration
- 8 days
- Dose studied
- 750 or 1500 mg/kg by gavage twice daily for 7 days and once on day 8
- Population
- Female BALB/c mice given paracetamol 300 mg/kg intraperitoneally on day 8 to induce acute liver injury; E. senticosus fruit extract at 750 or 1500 mg/kg orally before the challenge, against paracetamol alone (paracetamol given to every treated arm); both doses together
Study record
- Design
- animal study, in vivo
- Species
- animal
- Population
- Female BALB/c mice, 8 weeks old, paracetamol-induced liver injury model
- Participants
- 25
- Comparator
- no treatment / placebo
- Duration
- 7 days
- Endpoints measured
- 22