Papers/PMID:41124973
Age- and dose-specific effects of caffeine on sleep: A meta-analysis of controlled crossover trials.
Sleep medicine2025The record
2 findings drawn from this paper, on 1 compound across 2 endpoints.
What it reported
How to read these marksWhat moved
2 findings
caffeine — decreases total sleep time
PreliminaryGrade D, Preliminary. Non-human or in vitro only.Findingreplicated ×1“Random-effects meta-analysis showed that caffeine significantly reduced total sleep time (mean difference [MD] = -34.67 min), sleep efficiency (MD = -4.74 %), and slow-wave sleep proportions (SWS%) (MD = -1.01 %), while prolonging sleep onset latency (MD = +8.35 min).”
Quoted verbatim from Age- and dose-specific effects of caffeine on sleep: A meta-analysis of controlled crossover trials.. - Study
- meta-analysis
- Population
- Healthy adults; acute caffeine versus placebo, nighttime polysomnography. Overall pooled estimate across 22 controlled crossover trials, not an age or dose subgroup. Instrument: polysomnography.
Age- and dose-specific effects of caffeine on sleep: A meta-analysis of controlled crossover trials.2025PMID:41124973
caffeine — increases sleep onset latency
PreliminaryGrade D, Preliminary. Non-human or in vitro only.Findingreplicated ×1“Random-effects meta-analysis showed that caffeine significantly reduced total sleep time (mean difference [MD] = -34.67 min), sleep efficiency (MD = -4.74 %), and slow-wave sleep proportions (SWS%) (MD = -1.01 %), while prolonging sleep onset latency (MD = +8.35 min).”
Quoted verbatim from Age- and dose-specific effects of caffeine on sleep: A meta-analysis of controlled crossover trials.. - Study
- meta-analysis
- Population
- Healthy adults; acute caffeine versus placebo, nighttime polysomnography. Overall pooled estimate across 22 controlled crossover trials, not an age or dose subgroup. Instrument: polysomnography.
Age- and dose-specific effects of caffeine on sleep: A meta-analysis of controlled crossover trials.2025PMID:41124973