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PapersPMID:41124973

Age- and dose-specific effects of caffeine on sleep: A meta-analysis of controlled crossover trials.

Sleep medicine2025The record ↗

01 · findings
2
02 · compound
1
03 · endpoints
2
04 · null
0
  1. Finding, very limited evidenceraisesSleep onset latency
  2. Finding, very limited evidencelowersTotal sleep time
Population, every finding
Healthy adults; acute caffeine versus placebo, nighttime polysomnography. Overall pooled estimate across 22 controlled crossover trials, not an age or dose subgroup. Instrument: polysomnography.

What moved

2 findingsHow to read these marks →
  • caffeine — increases sleep onset latency

    very limitedFindingreplicated ×1

    “Random-effects meta-analysis showed that caffeine significantly reduced total sleep time (mean difference [MD] = -34.67 min), sleep efficiency (MD = -4.74 %), and slow-wave sleep proportions (SWS%) (MD = -1.01 %), while prolonging sleep onset latency (MD = +8.35 min).”
    Quoted verbatim from Age- and dose-specific effects of caffeine on sleep: A meta-analysis of controlled crossover trials.
    Study
    meta-analysis

    Permalink

  • caffeine — decreases total sleep time

    very limitedFindingreplicated ×2

    “Random-effects meta-analysis showed that caffeine significantly reduced total sleep time (mean difference [MD] = -34.67 min), sleep efficiency (MD = -4.74 %), and slow-wave sleep proportions (SWS%) (MD = -1.01 %), while prolonging sleep onset latency (MD = +8.35 min).”
    Quoted verbatim from Age- and dose-specific effects of caffeine on sleep: A meta-analysis of controlled crossover trials.
    Study
    meta-analysis

    Permalink

Study record

Read under
caffeine
Design
meta-analysis
Species
human
Population
Healthy adults in controlled crossover trials measuring nighttime polysomnography after acute caffeine or placebo
Participants
956
Comparator
placebo
Duration
not recorded
Endpoints measured
7
Record
declined
Declined
another reason, stated per paper
Readings recorded
1