Papers/PMID:40892912
Structural insights into the substrate uptake and inhibition of the human creatine transporter (hCRT).
Proceedings of the National Academy of Sciences of the United States of America2025The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
creatine — is transported by SLC6A8
SpeculativeGrade F, Speculative. Mechanistic inference, no evidence found, or evidence weakened below D.Hypothesis“Creatine is transported into cells by the human creatine transporter (hCRT) (SLC6A8), an Na+/Cl--dependent symporter encoded on the X chromosome.”
Quoted verbatim from Structural insights into the substrate uptake and inhibition of the human creatine transporter (hCRT).. - Study
- mechanistic · not in humans
- Population
- purified recombinant human creatine transporter (hCRT/SLC6A8), cryo-EM structural study (apo, creatine-bound, RGX202-bound)
Structural insights into the substrate uptake and inhibition of the human creatine transporter (hCRT).2025PMID:40892912Permalink