PapersPMID:40851370
Accumulation of newly synthesized docosahexaenoic acid plays an essential role in heart regeneration.
- 01 · finding
- 1
- 02 · compound
- 1
- 03 · endpoint
- 1
- 04 · null
- 0
all-cis-docosa-4,7,10,13,16,19-hexaenoic acidWhat moved
1 findingHow to read these marks →all-cis-docosa-4,7,10,13,16,19-hexaenoic acid — binds PPARD
insufficientHypothesis
“Molecular docking, molecular dynamics simulations, and mutagenesis experiments suggest that DHA binds to PPARD in a distinct manner compared to OA, which may help explain their differing abilities to influence the expression of heart regeneration genes.”
Quoted verbatim from Accumulation of newly synthesized docosahexaenoic acid plays an essential role in heart regeneration.. - Study
- mechanistic · not in humans
- Population
- computational molecular docking, molecular dynamics simulation, and mutagenesis experiments
Study record
- Design, as each reading recorded it
- in vitro / mechanistic study
- Species
- cells / mixed / none
- Population
- cardiomyocytes (assay system for the promoter-binding/expression readout not further specified in abstract)
- Participants
- not recorded
- Comparator
- not stated in the paper / placebo
- Duration
- not recorded
- Endpoints
- 3
- Record
- extracted
- Readings recorded
- 2