PapersPMID:40044446
An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Controlled Trials Investigating the Effect of Curcumin Supplementation on Lipid Profiles.
curcuminWhat moved
1 findingHow to read these marks →- Increases HDL cholesterol
limitedreplicated ×2
“The updated MA showed that curcumin significantly increased HDL-c in overall patients, with an MD of 2.4 mg/dL (95% CI: 1.22, 3.57; I2 = 94%).”
- Study
- meta-analysis
- Effect
- 2.4 mean difference, 95% CI 1.22 to 3.57
- Dose studied
- pooled across whole curcumin 500 to 3000 mg/day, curcumin extract 45 to 6000 mg/day and bioavailability-enhanced forms (including curcumin with piperine, nano-curcumin, phytosomal, micellar)
- Population
- Adults in 72 randomised trials (87 arms) comparing curcumin supplementation with placebo or standard treatment, in healthy individuals and in patients with obesity, MAFLD, PCOS, metabolic syndrome, prediabetes or type 2 diabetes, ASCVD risk, CKD or dyslipidaemia; median follow-up 8 weeks
Study record
- Design
- meta-analysis
- Species
- human
- Population
- Adults in 72 randomized trials (87 arms) of curcumin supplementation (whole compound, curcumin extract, bioavailability-enhanced forms) versus placebo or standard treatment, re-pooled from 26 systematic reviews plus 19 new trials; healthy individuals and patients with obesity, MAFLD, PCOS, metabolic syndrome, prediabetes or T2D, ASCVD risk, CKD or dyslipidemia
- Participants
- not reported
- Comparator
- placebo
- Duration
- not reported
- Endpoints measured
- 54