PapersPMID:39978467
Acute decrease in the plasma tryptophan-to-large-neutral-amino-acids ratio attenuates the effects of L-tryptophan on gut hormones and energy intake in healthy males: a randomized, cross-over, exploratory trial.
What moved
1 findingHow to read these marks →- Decreases ad libitum test-meal energy intake
very limited
“Only Trp reduced energy intake [kcal (mean ± standard error of the mean); control: 1085 ± 49, Trp: 881 ± 75, Trp + Leu - 0.22: 963 ± 57, Trp + Leu - 0.45: 932 ± 60] compared with control (P = 0.008).”
- Study
- crossover
- Dose studied
- Trp 0.15 kcal/min intraduodenal infusion for 90 min
- Population
- Twelve healthy normal-weight males; ad-libitum energy intake immediately after a 90-min intraduodenal infusion; control was isotonic 0.9% saline
Study record
- Design
- crossover trial
- Species
- human
- Population
- Twelve healthy normal-weight males; intraduodenal infusion of L-tryptophan (Trp) alone against isotonic saline control is supplementation; Trp + Leu arms are combinations
- Participants
- 12
- Comparator
- placebo
- Duration
- not reported
- Endpoints measured
- 11