L-tryptophan decreases ad libitum test-meal energy intake

lowersVery limited evidenceFindingreplicated ×1

01 · The sentence it was drawn from

“Only Trp reduced energy intake [kcal (mean ± standard error of the mean); control: 1085 ± 49, Trp: 881 ± 75, Trp + Leu - 0.22: 963 ± 57, Trp + Leu - 0.45: 932 ± 60] compared with control (P = 0.008).”

Quoted verbatim from Acute decrease in the plasma tryptophan-to-large-neutral-amino-acids ratio attenuates the effects of L-tryptophan on gut hormones and energy intake in healthy males: a randomized, cross-over, exploratory trial.

This finding among the 9 findings on its endpoint

L-tryptophan

Ad libitum test-meal energy intake

lowers

Who: Twelve healthy normal-weight males; ad-libitum energy intake immediately after a 90-min intraduodenal infusion; control was isotonic 0.9% saline
Dose studied: Trp 0.15 kcal/min intraduodenal infusion for 90 min

Very limited evidencePMID 39978467 · 2025

02 · The study

Study: crossover
Duration: not reported

Evidence, by strength

strong
moderate
limited
very limitedthis finding
insufficient

03 · The paper

The American journal of clinical nutrition

Acute decrease in the plasma tryptophan-to-large-neutral-amino-acids ratio attenuates the effects of L-tryptophan on gut hormones and energy intake in healthy males: a randomized, cross-over, exploratory trial.

2025PMID 39978467doi 10.1016/j.ajcnut.2025.02.016

What else it reported1 finding · 1 compound · 1 endpoint

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M70JFCYSFMTAAA7KYQCYQ6RN