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CompoundsSubstances with curated findings
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The evidence graph for human biochemistry. Every edge carries its source, its study design, and a grade computed from both.

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Papers/PMID:39683542

Influence of CReatine Supplementation on mUScle Mass and Strength After Stroke (ICaRUS Stroke Trial): A Randomized Controlled Trial.

Nutrients2024The record

1 finding drawn from this paper, on 1 compound across 1 endpoint.

creatine

What it reported

How to read these marks

What moved

1 finding

creatine — increases serum creatinine concentration
LikelyGrade B, Likely. Human evidence, limited replication or design limits.Findingreplicated ×3
“Regarding the biochemical tests, creatine supplementation was associated with higher serum creatinine levels (p = 0.04) and decreased PGRN (p = 0.04) compared to the placebo group.”
Quoted verbatim from Influence of CReatine Supplementation on mUScle Mass and Strength After Stroke (ICaRUS Stroke Trial): A Randomized Controlled Trial..
Study

RCT
Duration

7 days
Dose

creatine 10 g orally twice daily during 7 days of hospitalisation
Population

adults aged 60 years and older hospitalised for acute ischaemic stroke; secondary endpoint
Influence of CReatine Supplementation on mUScle Mass and Strength After Stroke (ICaRUS Stroke Trial): A Randomized Controlled Trial.2024PMID:39683542