Papers/PMID:39567688
Human HDAC6 senses valine abundancy to regulate DNA damage.
Nature2025The record
1 finding drawn from this paper, on 1 compound across 1 endpoint.
What it reported
How to read these marksWhat moved
1 finding
L-valine — binds HDAC6
SpeculativeGrade F, Speculative. Mechanistic inference, or no evidence found.Finding“Here we identify that human histone deacetylase 6 (HDAC6) serves as a valine sensor by directly binding valine through a primate-specific SE14 repeat domain.”
Quoted verbatim from Human HDAC6 senses valine abundancy to regulate DNA damage.. - Study
- in vitro · not in humans
- Population
- human HDAC6 protein (exact binding-assay system not specified in the abstract)
Human HDAC6 senses valine abundancy to regulate DNA damage.2025PMID:39567688