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PapersPMID:39415242

N-acetylcysteine supplementation improves endocrine-metabolism profiles and ovulation induction efficacy in polycystic ovary syndrome.

Journal of ovarian research2024The record ↗

  1. Finding, moderate evidenceraisesClinical pregnancy rate

What moved

1 findingHow to read these marks →
  • Increases clinical pregnancy rate

    moderate

    “In the comparison of clinical pregnancy rates, both per OI cycle and cumulative per patient, the rates in the NAC group were significantly greater than those in the control group (30.99% vs. 23.30%, p = 0.040; and 77.88% vs. 58.04%, p = 0.001, respectively).”
    Study
    RCT
    Dose studied
    1.8 g/day oral (0.6 g three times daily) from day 2 to 4 of the cycle for five consecutive days, each induction cycle
    Population
    Women aged 21 to 38 with polycystic ovary syndrome and anovulation or oligo-ovulation undergoing letrozole plus urinary FSH ovulation induction (up to three cycles) in both arms; pragmatic open-label trial with blinded outcome assessors and a no-NAC control group (human arm only)

Study record

Design
randomised controlled trial
Species
mixed
Population
Letrozole-induced PCOS C57BL/6 mice, and women with PCOS and anovulation or oligo-ovulation undergoing ovulation induction (pragmatic randomized trial)
Participants
230
Comparator
no treatment
Duration
not reported
Endpoints measured
33