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Catalyst

N-acetyl-L-cysteineFinding

N-acetyl-L-cysteine increases clinical pregnancy rate

raisesModerate evidenceFinding

01 · The sentence it was drawn from

“In the comparison of clinical pregnancy rates, both per OI cycle and cumulative per patient, the rates in the NAC group were significantly greater than those in the control group (30.99% vs. 23.30%, p = 0.040; and 77.88% vs. 58.04%, p = 0.001, respectively).”
Quoted verbatim from N-acetylcysteine supplementation improves endocrine-metabolism profiles and ovulation induction efficacy in polycystic ovary syndrome.
This finding among the 11 findings on its endpoint

N-acetyl-L-cysteine

Clinical pregnancy rate

raises

Who
Women aged 21 to 38 with polycystic ovary syndrome and anovulation or oligo-ovulation undergoing letrozole plus urinary FSH ovulation induction (up to three cycles) in both arms; pragmatic open-label trial with blinded outcome assessors and a no-NAC control group (human arm only)
Dose studied
1.8 g/day oral (0.6 g three times daily) from day 2 to 4 of the cycle for five consecutive days, each induction cycle

Moderate evidencePMID 39415242 · 2024

02 · The study

Study
RCT
Duration
not reported

Evidence, by strength

  • strong
  • moderatethis finding
  • limited
  • very limited
  • insufficient

03 · The paper

Journal of ovarian research
What else it reported1 finding · 1 compound · 1 endpoint

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M6Y08VP5Z1CEDMDNFAVPJ155