PapersPMID:39341000
Higher dietary choline intake is associated with increased risk of all-cause and cause-specific mortality: A systematic review and dose-response meta-analysis of cohort studies.
- findings
- 2
- compound
- 1
- endpoints
- 2
choline- Study, every finding
- meta-analysis
- Dose studied, every finding
- each 100 mg/day increase in dietary choline intake
- Population, every finding
- Participants in six prospective cohort studies of habitual dietary choline intake; linear dose-response per 100 mg/day
What moved
How to read these marks →“The linear dose-response analysis showed that each 100 mg/day increase in choline intake was significantly associated with 6% and 11% increases in risk of all-cause (RR = 1.06, 95% CI: 1.03, 1.10, I2 =83.7%, P < .001) and cardiovascular diseases mortality (RR = 1.11, 95% CI: 1.06, 1.16, I2 = 54.3%, P = .02) respectively.”
- Increases cardiovascular mortality
very limited
- Effect
- 1.11 risk ratio, 95% CI 1.06 to 1.16
- Increases all-cause mortality
very limited
- Effect
- 1.06 risk ratio, 95% CI 1.03 to 1.1
Study record
- Design
- meta-analysis
- Species
- human
- Population
- Six cohort studies of dietary choline and betaine intake and mortality
- Participants
- 482,778
- Comparator
- observational
- Duration
- not reported
- Endpoints measured
- 4