PapersPMID:39259767
Choline Metabolites and 15-Year Risk of Incident Diabetes in a Prospective Cohort of Adults: Coronary Artery Risk Development in Young Adults (CARDIA) Study.
cholineNo finding here moved its endpoint.
What did not
1 findingHow to read these marks →“In analysis of metabolites modeled continuous, choline was not associated (HR 1.05 [95% CI 0.94, 1.16]), while betaine was inversely associated (0.76 [0.67, 0.88]) and ln-TMAO was positively associated (1.11 [1.01, 1.22]) with 15-year risk of incident diabetes (Table 2).”
- Study
- cohort
- Participants
- 3,133
- Effect
- 1.05 hazard ratio, 95% CI 0.94 to 1.16
- Interests
- Industry funded
- Dose studied
- endogenous plasma choline concentration, per 1-SD increase
- Population
- 3,133 adults aged 33-45 years free of diabetes at year 15 of the CARDIA cohort (387 incident cases over 15 years); plasma choline measured at baseline by LC-MS, per 1-SD, adjusted model 2
Study record
- Design
- cohort study
- Species
- human
- Population
- CARDIA participants free of diabetes at year 15 (aged 33-45 years) with plasma choline metabolite data
- Participants
- 3,133
- Comparator
- observational
- Duration
- 5,479 days
- Endpoints measured
- 35