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Catalyst

cholineFinding

Choline has no detected effect on type 2 diabetes incidence

no difference foundLimited evidenceFindingreplicated ×1

01 · The sentence it was drawn from

“In analysis of metabolites modeled continuous, choline was not associated (HR 1.05 [95% CI 0.94, 1.16]), while betaine was inversely associated (0.76 [0.67, 0.88]) and ln-TMAO was positively associated (1.11 [1.01, 1.22]) with 15-year risk of incident diabetes (Table 2).”
Quoted verbatim from Choline Metabolites and 15-Year Risk of Incident Diabetes in a Prospective Cohort of Adults: Coronary Artery Risk Development in Young Adults (CARDIA) Study.
This finding among the 13 findings on its endpoint

choline

Type 2 diabetes incidence

no difference found

Effect as reported

1.05hazard ratio

CI 0.94 to 1.16

Who
n = 3,133 · 3,133 adults aged 33-45 years free of diabetes at year 15 of the CARDIA cohort (387 incident cases over 15 years); plasma choline measured at baseline by LC-MS, per 1-SD, adjusted model 2
Dose studied
endogenous plasma choline concentration, per 1-SD increase

Limited evidencePMID 39259767 · 2024

02 · The study

Study
cohort
Participants
3,133
Duration
not reported

Evidence, by strength

  • strong
  • moderate
  • limitedthis finding
  • very limited
  • insufficient

03 · The paper

Diabetes care
What else it reported1 finding · 1 compound · 1 endpoint

04 · To cite this finding

This address does not change

https://catalystproject.ai/e/01M6Y08MZ5BBG5PEZ5MK6HYJCV