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PapersPMID:39129455

Clinical evidence of coenzyme Q10 pretreatment for women with diminished ovarian reserve undergoing IVF/ICSI: a systematic review and meta-analysis.

Annals of medicine2024The record ↗

  1. Finding, moderate evidenceraisesClinical pregnancy rate

What moved

1 findingHow to read these marks →
  • Increases clinical pregnancy rate

    moderate

    “The forest plot of intervention effects on IVF/ICSI outcomes suggested that CoQ10 pretreatment was efficacious in improving clinical pregnancy rate (OR = 1.84, 95%CI [1.33, 2.53], p = 0.0002, I2 = 29%).”
    Study
    meta-analysis
    Effect
    1.84 odds ratio, 95% CI 1.33 to 2.53
    Dose studied
    CoQ10 pretreatment for 60 days (alone) or three months (with DHEA, vitamin E or femoston) before ovarian stimulation; dose not stated in the text supplied
    Population
    Women with diminished ovarian reserve undergoing IVF or ICSI; six randomised trials pooled. Five trials gave CoQ10 with DHEA, vitamin E or femoston against the same agent alone; one trial gave CoQ10 alone against no treatment

Study record

Design
meta-analysis
Species
human
Population
Women with diminished ovarian reserve (AFC<5-7 or FSH>=10 IU/L or AMH<1.1 ng/mL) undergoing IVF/ICSI, across 6 RCTs conducted in China
Participants
1,529
Comparator
no treatment / not stated in the paper
Duration
not reported
Endpoints measured
9