Papers/PMID:39053932
Curcumin attenuates lupus nephritis by inhibiting neutrophil migration via PI3K/AKT/NF-κB signalling pathway.
Lupus science & medicine2024The record
2 findings · 1 compound · 2 endpoints
What it reported
How to read these marksWhat moved
2 findings
curcumin — decreases interleukin-6 concentration
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Findingreplicated ×6“As expected, the ELISA results showed that the concentrations of the ds-DNA antibody, IL-6 and IFN-γ were notably lower in the curcumin treatment group than in the control group.”
Quoted verbatim from Curcumin attenuates lupus nephritis by inhibiting neutrophil migration via PI3K/AKT/NF-κB signalling pathway.. - Study
- animal · not in humans
- Duration
- 14 days
- Dose
- 50 mg/kg daily, intraperitoneal, dissolved in DMSO
- Population
- MRL/lpr lupus mice treated daily with curcumin or vehicle for 2 weeks; serum measured by ELISA
Curcumin attenuates lupus nephritis by inhibiting neutrophil migration via PI3K/AKT/NF-κB signalling pathway.2024PMID:39053932Permalink
curcumin — decreases serum creatinine concentration
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“Consistently, treatment with curcumin significantly decreased the level of serum creatinine compared to that in the vehicle group.”
Quoted verbatim from Curcumin attenuates lupus nephritis by inhibiting neutrophil migration via PI3K/AKT/NF-κB signalling pathway.. - Study
- animal · not in humans
- Duration
- 14 days
- Dose
- 50 mg/kg daily, intraperitoneal, dissolved in DMSO
- Population
- MRL/lpr lupus mice treated daily with curcumin or vehicle for 2 weeks; serum creatinine measured by ELISA
Curcumin attenuates lupus nephritis by inhibiting neutrophil migration via PI3K/AKT/NF-κB signalling pathway.2024PMID:39053932Permalink