Papers/PMID:38716985
Coenzyme Q10 prevents RANKL-induced osteoclastogenesis by promoting autophagy via inactivation of the PI3K/AKT/mTOR and MAPK pathways.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas2024The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
coenzyme Q10 — inhibits MTOR
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“As demonstrated in Figure 4A-C, the findings revealed that the relative phosphorylation levels of PI3K, AKT, and mTOR were significantly lower in the RANKL + CoQ10 group than in the RANKL group (all P<0.05).”
Quoted verbatim from Coenzyme Q10 prevents RANKL-induced osteoclastogenesis by promoting autophagy via inactivation of the PI3K/AKT/mTOR and MAPK pathways.. - Study
- in vitro · not in humans
- Dose
- 10-3 M
- Population
- RAW264.7 mouse macrophage cells treated with 50 ng/mL RANKL, with or without 10-3 M CoQ10
Coenzyme Q10 prevents RANKL-induced osteoclastogenesis by promoting autophagy via inactivation of the PI3K/AKT/mTOR and MAPK pathways.2024PMID:38716985Permalink