coenzyme Q10/Finding
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A single claim from the graph, with the evidence strength computed from its study, the sentence it was drawn from, and the paper. This address does not change.
Inhibits MTOR
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“As demonstrated in Figure 4A-C, the findings revealed that the relative phosphorylation levels of PI3K, AKT, and mTOR were significantly lower in the RANKL + CoQ10 group than in the RANKL group (all P<0.05).”
Quoted verbatim from Coenzyme Q10 prevents RANKL-induced osteoclastogenesis by promoting autophagy via inactivation of the PI3K/AKT/mTOR and MAPK pathways.. - Study
- in vitro · not in humans
- Dose
- 10-3 M
- Population
- RAW264.7 mouse macrophage cells treated with 50 ng/mL RANKL, with or without 10-3 M CoQ10
Coenzyme Q10 prevents RANKL-induced osteoclastogenesis by promoting autophagy via inactivation of the PI3K/AKT/mTOR and MAPK pathways.2024PMID:38716985Permalink
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To cite this finding: https://catalystproject.ai/e/01M4Q1WNMYQ38KJ7P1C74PCWN3