PapersPMID:38632262
Malnutrition enteropathy in Zambian and Zimbabwean children with severe acute malnutrition: A multi-arm randomized phase II trial.
What moved
1 findingHow to read these marks →“Amongst secondary biomarker endpoints (Table 4), compared with standard care, budesonide reduced plasma CRP (mean reduction 5.2 mg/L; 90%CI 0.8, 9.6; P = 0.05) and sCD163 (mean reduction 405 ng/mL; 90%CI 73, 738; P = 0.05) while colostrum and N-acetyl glucosamine had effects only on CRP (reductions 5.9 mg/L; 90%CI 1.4, 10.3; P = 0.03, and 4.8 mg/L; 90%CI 0.5, 9.2; P = 0.07, respectively).”
- Study
- RCT
- Duration
- 14 days
- Interests
- An author is affiliated with a producer
- Dose studied
- 1.5 g 8-hourly (4.5 g/day), orally or by nasogastric tube, 14 days
- Population
- Children aged 6-59 months hospitalised with complicated severe acute malnutrition in Zambia and Zimbabwe; colostrum added to standard care and compared with standard care only; day 15 plasma CRP, per-protocol ANCOVA against standard care
Study record
- Design
- randomised controlled trial
- Species
- human
- Population
- Children aged 6-59 months hospitalised with complicated severe acute malnutrition in Lusaka (Zambia) and Harare (Zimbabwe); colostrum arm received bovine colostrum powder
- Participants
- 125
- Comparator
- no treatment
- Duration
- 14 days
- Endpoints measured
- 72