Papers/PMID:38570276
Berberine inhibits NLRP3 inflammasome activation and proinflammatory macrophage M1 polarization to accelerate peripheral nerve regeneration.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2024The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
berberine — inhibits NLRP3
SpeculativeGrade F, Speculative. Mechanistic inference, no evidence found, or evidence weakened below D.Findingreplicated ×1“The qRT-PCR results showed that BBR dose-dependently inhibited the mRNA expression of NLRP3 and its linked molecules, including IL-1β, caspase-1, ASC, and GSDMAD.”
Quoted verbatim from Berberine inhibits NLRP3 inflammasome activation and proinflammatory macrophage M1 polarization to accelerate peripheral nerve regeneration.. - Study
- animal · not in humans
- Duration
- 4 weeks
- Dose
- 60-240 mg/kg/day, daily oral gavage, days 1-28
- Population
- C57BL/6J mice with sciatic nerve crush injury (peripheral nerve injury), injury-site tissue
Berberine inhibits NLRP3 inflammasome activation and proinflammatory macrophage M1 polarization to accelerate peripheral nerve regeneration.2024PMID:38570276Permalink