berberine/Finding
One finding, on its own
A single claim from the graph, with the grade computed from its study, the sentence it was drawn from, and the paper. This address does not change.
Inhibits NLRP3
SpeculativeGrade F, Speculative. Mechanistic inference, no evidence found, or evidence weakened below D.Findingreplicated ×1“The qRT-PCR results showed that BBR dose-dependently inhibited the mRNA expression of NLRP3 and its linked molecules, including IL-1β, caspase-1, ASC, and GSDMAD.”
Quoted verbatim from Berberine inhibits NLRP3 inflammasome activation and proinflammatory macrophage M1 polarization to accelerate peripheral nerve regeneration.. - Study
- animal · not in humans
- Duration
- 4 weeks
- Dose
- 60-240 mg/kg/day, daily oral gavage, days 1-28
- Population
- C57BL/6J mice with sciatic nerve crush injury (peripheral nerve injury), injury-site tissue
Berberine inhibits NLRP3 inflammasome activation and proinflammatory macrophage M1 polarization to accelerate peripheral nerve regeneration.2024PMID:38570276Permalink
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To cite this finding: https://catalystproject.ai/e/01M3P2TT9FXN58P9QM1XHTXMKY