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PapersPMID:38398813

Formulated Palmitoylethanolamide Supplementation Improves Parameters of Cognitive Function and BDNF Levels in Young, Healthy Adults: A Randomised Cross-Over Trial.

Nutrients2024The record ↗

  1. Finding, limited evidenceraisesBrain-derived neurotrophic factor (BDNF) concentration

What moved

1 findingHow to read these marks →
  • “Following six weeks of supplementation with Levagen+® PEA, the expression of serum BDNF significantly increased by 2.76 ± 6.12 ng/mL (p = 0.0005) compared with no change in the placebo (−0.72 ± 7.16 ng/mL; p = 0.39).”
    Study
    crossover
    Participants
    39
    Duration
    6 weeks
    Interests
    Industry funded
    Dose studied
    Levagen+ (formulated PEA), 2 capsules daily, 600 mg PEA total daily dose, oral, 6 weeks
    Population
    Healthy young university students in London, randomised double-blind placebo-controlled crossover, 6-week arms with 6-week washout; placebo was microcrystalline cellulose capsules

Study record

Design
crossover trial
Species
human
Population
Healthy full-time university students in London, aged 18 years and above
Participants
39
Comparator
placebo
Duration
42 days
Endpoints measured
16