PapersPMID:38252787
The origin of vitamin B12 levels and risk of all-cause, cardiovascular and cancer specific mortality: A systematic review and dose-response meta-analysis.
What moved
1 findingHow to read these marks →- Increases all-cause mortality
very limited
“The meta-analysis of cohort studies showed a positive association between a high serum vitamin B12 concentration (>600 pmol/L) and all-cause mortality (adjusted HR 1.50, 95 % CI 1.29 to 1.74; n = 10; p < 0.01), CVD mortality (adjusted HR 2.04, 95 % CI 0.99 to 4.19; n = 2; p = 0.02), except cancer mortality (adjusted HR 1.56, 95 % CI 0.82 to 2.95; n = 3).”
- Study
- meta-analysis
- Effect
- 1.5 hazard ratio, 95% CI 1.29 to 1.74
- Population
- Pooled cohort studies of adults; high circulating serum vitamin B12 category (>600 pmol/L) versus the reference category; no one was dosed
Study record
- Design
- meta-analysis
- Species
- human
- Population
- Twenty-two cohort studies of general population and older adults with serum vitamin B12 measured
- Participants
- 92,346
- Comparator
- observational
- Duration
- not reported
- Endpoints measured
- 6