Papers/PMID:38216185
Effect of methylene blue on outcomes in patients with distributive shock: a meta-analysis of randomised controlled trials.
BMJ open2024The record
3 findings · 1 compound · 3 endpoints
What it reported
How to read these marksWhat moved
3 findings
methylene blue — decreases intensive care unit length of stay
StrongEvidence strength: strong. Randomised human trials or their synthesis, with the effect's size and interval recorded and no recorded weakness outstanding.Finding“The results showed that MB reduced the ICU LOS in patients with distributive shock (MD: −1.54; 95% CI −2.61 to −0.48; p=0.004; I2=25%; table 2).”
Quoted verbatim from Effect of methylene blue on outcomes in patients with distributive shock: a meta-analysis of randomised controlled trials.. - Study
- meta-analysis
- Participants
- 141
- Population
- adults with distributive shock (septic shock, vasoplegic syndrome, ischaemia-reperfusion injury); secondary endpoint; 3 trials, n = 141
Effect -1.54 mean difference, 95% CI -2.61 to -0.48
Effect of methylene blue on outcomes in patients with distributive shock: a meta-analysis of randomised controlled trials.2024PMID:38216185Permalink
methylene blue — decreases hospital length of stay
StrongEvidence strength: strong. Randomised human trials or their synthesis, with the effect's size and interval recorded and no recorded weakness outstanding.Findingreplicated ×1“The results showed that MB reduced the hospital LOS in patients with distributive shock (MD: −1.97; 95% CI −3.82 to −0.11; p=0.04; table 2).”
Quoted verbatim from Effect of methylene blue on outcomes in patients with distributive shock: a meta-analysis of randomised controlled trials.. - Study
- meta-analysis
- Participants
- 111
- Population
- adults with distributive shock (septic shock, vasoplegic syndrome, ischaemia-reperfusion injury); secondary endpoint; 2 trials, n = 111
Effect -1.97 mean difference, 95% CI -3.82 to -0.11
Effect of methylene blue on outcomes in patients with distributive shock: a meta-analysis of randomised controlled trials.2024PMID:38216185Permalink
methylene blue — decreases duration of mechanical ventilation
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“The results showed that compared with placebo, MB reduced the duration of mechanical ventilation during hospitalisation in patients with distributive shock (MD: −0.68; 95% CI −1.23 to −0.14; p=0.01; I2=0%; online supplemental figure S3).”
Quoted verbatim from Effect of methylene blue on outcomes in patients with distributive shock: a meta-analysis of randomised controlled trials.. - Study
- meta-analysis
- Population
- adults with distributive shock (septic shock, vasoplegic syndrome, ischaemia-reperfusion injury); secondary endpoint; 3 trials
Effect -0.68 mean difference, 95% CI -1.23 to -0.14
Effect of methylene blue on outcomes in patients with distributive shock: a meta-analysis of randomised controlled trials.2024PMID:38216185Permalink