Papers/PMID:38216185
Effect of methylene blue on outcomes in patients with distributive shock: a meta-analysis of randomised controlled trials.
BMJ open2024The record
3 findings drawn from this paper, on 1 compound across 3 endpoints.
What it reported
How to read these marksWhat moved
3 findings
methylene blue — decreases intensive care unit length of stay
Well establishedGrade A, Well established. Replicated human trial evidence, consistent direction.Finding“The results showed that MB reduced the ICU LOS in patients with distributive shock (MD: −1.54; 95% CI −2.61 to −0.48; p=0.004; I2=25%; table 2).”
Quoted verbatim from Effect of methylene blue on outcomes in patients with distributive shock: a meta-analysis of randomised controlled trials.. - Study
- meta-analysis
- Participants
- 141
- Population
- adults with distributive shock (septic shock, vasoplegic syndrome, ischaemia-reperfusion injury); secondary endpoint; 3 trials, n = 141
Effect -1.54 mean difference, 95% CI -2.61 to -0.48
Effect of methylene blue on outcomes in patients with distributive shock: a meta-analysis of randomised controlled trials.2024PMID:38216185
methylene blue — decreases hospital length of stay
Well establishedGrade A, Well established. Replicated human trial evidence, consistent direction.Findingreplicated ×1“The results showed that MB reduced the hospital LOS in patients with distributive shock (MD: −1.97; 95% CI −3.82 to −0.11; p=0.04; table 2).”
Quoted verbatim from Effect of methylene blue on outcomes in patients with distributive shock: a meta-analysis of randomised controlled trials.. - Study
- meta-analysis
- Participants
- 111
- Population
- adults with distributive shock (septic shock, vasoplegic syndrome, ischaemia-reperfusion injury); secondary endpoint; 2 trials, n = 111
Effect -1.97 mean difference, 95% CI -3.82 to -0.11
Effect of methylene blue on outcomes in patients with distributive shock: a meta-analysis of randomised controlled trials.2024PMID:38216185
methylene blue — decreases duration of mechanical ventilation
LikelyGrade B, Likely. Human evidence, limited replication or design limits.Finding“The results showed that compared with placebo, MB reduced the duration of mechanical ventilation during hospitalisation in patients with distributive shock (MD: −0.68; 95% CI −1.23 to −0.14; p=0.01; I2=0%; online supplemental figure S3).”
Quoted verbatim from Effect of methylene blue on outcomes in patients with distributive shock: a meta-analysis of randomised controlled trials.. - Study
- meta-analysis
- Population
- adults with distributive shock (septic shock, vasoplegic syndrome, ischaemia-reperfusion injury); secondary endpoint; 3 trials
Effect -0.68 mean difference, 95% CI -1.23 to -0.14
Effect of methylene blue on outcomes in patients with distributive shock: a meta-analysis of randomised controlled trials.2024PMID:38216185