Papers/PMID:38200253
The impact of piperine on the metabolic conditions of patients with NAFLD and early cirrhosis: a randomized double-blind controlled trial.
Scientific reports2024The record
4 findings · 1 compound · 4 endpoints
What it reported
How to read these marksWhat moved
4 findings
piperine — decreases alanine aminotransferase
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“After the trial interval, concentrations of ALT and AST in the case group were statistically decreased compared with the control group with a P value < 0.001 and a P value of 0.002, respectively.”
Quoted verbatim from The impact of piperine on the metabolic conditions of patients with NAFLD and early cirrhosis: a randomized double-blind controlled trial.. - Study
- RCT
- Duration
- 3 months
- Dose
- 5 mg piperine capsule daily
- Population
- Adults with ultrasound grade 2-3 NAFLD and raised ALT, Iran
The impact of piperine on the metabolic conditions of patients with NAFLD and early cirrhosis: a randomized double-blind controlled trial.2024PMID:38200253Permalink
piperine — decreases aspartate aminotransferase
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“After the trial interval, concentrations of ALT and AST in the case group were statistically decreased compared with the control group with a P value < 0.001 and a P value of 0.002, respectively.”
Quoted verbatim from The impact of piperine on the metabolic conditions of patients with NAFLD and early cirrhosis: a randomized double-blind controlled trial.. - Study
- RCT
- Duration
- 3 months
- Dose
- 5 mg piperine capsule daily
- Population
- Adults with ultrasound grade 2-3 NAFLD and raised ALT, Iran
The impact of piperine on the metabolic conditions of patients with NAFLD and early cirrhosis: a randomized double-blind controlled trial.2024PMID:38200253Permalink
piperine — decreases triglycerides
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Serum concentrations of cholesterol, LDL, and TG were significantly reduced after the timeline of intervention in participants of case arm in comparison to the participants of control arm (P value < 0.001, P value = 0.043, P value = 0.005, respectively).”
Quoted verbatim from The impact of piperine on the metabolic conditions of patients with NAFLD and early cirrhosis: a randomized double-blind controlled trial.. - Study
- RCT
- Duration
- 3 months
- Dose
- 5 mg piperine capsule daily
- Population
- Adults with ultrasound grade 2-3 NAFLD and raised ALT, Iran; blood drawn after 12 h overnight fast
The impact of piperine on the metabolic conditions of patients with NAFLD and early cirrhosis: a randomized double-blind controlled trial.2024PMID:38200253Permalink
piperine — decreases fasting blood glucose
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Serum levels of FBS significantly declined in case arm in comparison to control arm after the trial timeline (P value = 0.011).”
Quoted verbatim from The impact of piperine on the metabolic conditions of patients with NAFLD and early cirrhosis: a randomized double-blind controlled trial.. - Study
- RCT
- Duration
- 3 months
- Dose
- 5 mg piperine capsule daily
- Population
- Adults with ultrasound grade 2-3 NAFLD and raised ALT, Iran; blood drawn after 12 h overnight fast
The impact of piperine on the metabolic conditions of patients with NAFLD and early cirrhosis: a randomized double-blind controlled trial.2024PMID:38200253Permalink