Papers/PMID:37207866
Lutein targeting orbital fibroblasts attenuates fibrotic and inflammatory effects in thyroid-associated ophthalmopathy.
Experimental eye research2023The record
4 findings · 1 compound · 4 endpoints
What it reported
How to read these marksWhat moved
4 findings
lutein — inhibits CCN2
SpeculativeGrade F, Speculative. Mechanistic inference, no evidence found, or evidence weakened below D.Finding“LU inhibited ACTA2, COL1A1, FN1, and CTGF mRNA expression and suppressed α-SMA, and FN1 protein expression induced by TGF-β1.”
Quoted verbatim from Lutein targeting orbital fibroblasts attenuates fibrotic and inflammatory effects in thyroid-associated ophthalmopathy.. - Study
- in vitro · not in humans
- Population
- orbital fibroblasts from patients with thyroid-associated ophthalmopathy, treated with TGF-β1 to induce fibrosis
Lutein targeting orbital fibroblasts attenuates fibrotic and inflammatory effects in thyroid-associated ophthalmopathy.2023PMID:37207866Permalink
lutein — inhibits COL1A1
SpeculativeGrade F, Speculative. Mechanistic inference, no evidence found, or evidence weakened below D.Finding“LU inhibited ACTA2, COL1A1, FN1, and CTGF mRNA expression and suppressed α-SMA, and FN1 protein expression induced by TGF-β1.”
Quoted verbatim from Lutein targeting orbital fibroblasts attenuates fibrotic and inflammatory effects in thyroid-associated ophthalmopathy.. - Study
- in vitro · not in humans
- Population
- orbital fibroblasts from patients with thyroid-associated ophthalmopathy, treated with TGF-β1 to induce fibrosis
Lutein targeting orbital fibroblasts attenuates fibrotic and inflammatory effects in thyroid-associated ophthalmopathy.2023PMID:37207866Permalink
lutein — inhibits FN1
SpeculativeGrade F, Speculative. Mechanistic inference, no evidence found, or evidence weakened below D.Finding“LU inhibited ACTA2, COL1A1, FN1, and CTGF mRNA expression and suppressed α-SMA, and FN1 protein expression induced by TGF-β1.”
Quoted verbatim from Lutein targeting orbital fibroblasts attenuates fibrotic and inflammatory effects in thyroid-associated ophthalmopathy.. - Study
- in vitro · not in humans
- Population
- orbital fibroblasts from patients with thyroid-associated ophthalmopathy, treated with TGF-β1 to induce fibrosis
Lutein targeting orbital fibroblasts attenuates fibrotic and inflammatory effects in thyroid-associated ophthalmopathy.2023PMID:37207866Permalink
lutein — inhibits ACTA2
SpeculativeGrade F, Speculative. Mechanistic inference, no evidence found, or evidence weakened below D.Finding“LU inhibited ACTA2, COL1A1, FN1, and CTGF mRNA expression and suppressed α-SMA, and FN1 protein expression induced by TGF-β1.”
Quoted verbatim from Lutein targeting orbital fibroblasts attenuates fibrotic and inflammatory effects in thyroid-associated ophthalmopathy.. - Study
- in vitro · not in humans
- Population
- orbital fibroblasts from patients with thyroid-associated ophthalmopathy, treated with TGF-β1 to induce fibrosis
Lutein targeting orbital fibroblasts attenuates fibrotic and inflammatory effects in thyroid-associated ophthalmopathy.2023PMID:37207866Permalink