Papers/PMID:37179010
Curcumin suppresses RANKL-induced osteoclast precursor autophagy in osteoclastogenesis by inhibiting RANK signaling and downstream JNK-BCL2-Beclin1 pathway.
Biomedical journal2024The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
curcumin — inhibits TRAF6
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“As shown in, curcumin inhibited TRAF6 protein expression in OCPs in a concentration-dependent manner in the presence of RANKL.”
Quoted verbatim from Curcumin suppresses RANKL-induced osteoclast precursor autophagy in osteoclastogenesis by inhibiting RANK signaling and downstream JNK-BCL2-Beclin1 pathway.. - Study
- in vitro · not in humans
- Dose
- 0, 5, 10 or 15 μM
- Population
- mouse bone marrow-derived osteoclast precursors (OCPs) cultured with M-CSF and RANKL; western blot
Curcumin suppresses RANKL-induced osteoclast precursor autophagy in osteoclastogenesis by inhibiting RANK signaling and downstream JNK-BCL2-Beclin1 pathway.2024PMID:37179010Permalink