Papers/PMID:36800965
Effect of vitamin E intake on glycemic control and insulin resistance in diabetic patients: an updated systematic review and meta-analysis of randomized controlled trials.
Nutrition journal2023The record
3 findings · 1 compound · 3 endpoints · 1 null
What it reported
How to read these marksWhat moved
2 findings
α-tocopherol — decreases glycated haemoglobin (HbA1c)
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Meta-analysis of these RCTs showed that vitamin E intake, compared with a placebo, resulted in a significant reduction in HbA1c in diabetic patients (MD: -0.21%, 95% CI: -0.33 to -0.09, P = 0.001, I2: 76.6%, P < 0.001).”
Quoted verbatim from Effect of vitamin E intake on glycemic control and insulin resistance in diabetic patients: an updated systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Population
- Adults with type 1 or type 2 diabetes, diabetic nephropathy or neuropathy; pooled randomised trials of vitamin E supplementation against a control group
Effect -0.21 mean difference, 95% CI -0.33 to -0.09
Effect of vitamin E intake on glycemic control and insulin resistance in diabetic patients: an updated systematic review and meta-analysis of randomized controlled trials.2023PMID:36800965Permalink
α-tocopherol — decreases HOMA-IR
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Combining results of these studies revealed that vitamin E intake reduced HOMA-IR in diabetic patients (MD: -0.44, 95% CI: -0.82 to -0.05, P = 0.02, I2: 83.4%, P < 0.001).”
Quoted verbatim from Effect of vitamin E intake on glycemic control and insulin resistance in diabetic patients: an updated systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Population
- Adults with type 1 or type 2 diabetes, diabetic nephropathy or neuropathy; pooled randomised trials of vitamin E supplementation against a control group
Effect -0.44 mean difference, 95% CI -0.82 to -0.05
Effect of vitamin E intake on glycemic control and insulin resistance in diabetic patients: an updated systematic review and meta-analysis of randomized controlled trials.2023PMID:36800965Permalink
What did not
1 finding
α-tocopherol — no detected effect on fasting blood glucose
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“Combining mean differences from these studies showed no significant effect of vitamin E on fasting blood glucose in diabetic patients with significant between-study heterogeneity (MD: -3.35 mg/dL, 95% CI: -8.10 to 1.40, P = 0.16, I2: 82.2%, P < 0.001).”
Quoted verbatim from Effect of vitamin E intake on glycemic control and insulin resistance in diabetic patients: an updated systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Population
- Adults with type 1 or type 2 diabetes, diabetic nephropathy or neuropathy; pooled randomised trials of vitamin E supplementation against a control group
Effect -3.35 mean difference, 95% CI -8.1 to 1.4
Effect of vitamin E intake on glycemic control and insulin resistance in diabetic patients: an updated systematic review and meta-analysis of randomized controlled trials.2023PMID:36800965Permalink