Papers/PMID:36296907
Moringa oleifera Improves MAFLD by Inducing Epigenetic Modifications.
Nutrients2022The record
3 findings · 1 compound · 3 endpoints
What it reported
How to read these marksWhat moved
3 findings
Moringa oleifera — decreases HOMA-IR
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Improvement in insulin sensitivity was corroborated calculating HOMA-IR, which was significantly reduced in the HF + MO treated group compared to the HF group (p < 0.05; Figure 1E).”
Quoted verbatim from Moringa oleifera Improves MAFLD by Inducing Epigenetic Modifications.. - Study
- animal · not in humans
- Duration
- 8 weeks
- Dose
- 150 uL of 62.5 mg/mL extract daily by orogastric cannula, calculated as 290 mg/kg
- Population
- Male C57BL/6J mice fed a high-fat diet with high-sugar drinking water for 16 weeks (NASH model); extract given for the final 8 weeks, compared with untreated high-fat-diet mice
Moringa oleifera Improves MAFLD by Inducing Epigenetic Modifications.2022PMID:36296907Permalink
Moringa oleifera — decreases aspartate aminotransferase
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“The group treated with Moringa showed reduction in AST and ALT levels compared to HF group, though significant reduction in AST levels was seen in the HF + MO group against the HF group (68.80 U/L ± 4.26 vs. 146.3 U/L ± 8.84 U/L; p < 0.05; Figure 2A).”
Quoted verbatim from Moringa oleifera Improves MAFLD by Inducing Epigenetic Modifications.. - Study
- animal · not in humans
- Duration
- 8 weeks
- Dose
- 150 uL of 62.5 mg/mL extract daily by orogastric cannula, calculated as 290 mg/kg
- Population
- Male C57BL/6J mice fed a high-fat diet with high-sugar drinking water for 16 weeks (NASH model); extract given for the final 8 weeks, compared with untreated high-fat-diet mice
Moringa oleifera Improves MAFLD by Inducing Epigenetic Modifications.2022PMID:36296907Permalink
Moringa oleifera — decreases serum leptin
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Noteworthy, insulin (7505 pg/mL ± 943.1 vs. 3335 pg/mL ± 889.2; p < 0.05, Figure 2D), PAI-1 (3824 pg/mL ± 867.2 vs. 1425 pg/mL ± 209.3; p < 0.05, Figure 2E) and leptin serum levels (44,373 pg/mL ± 5129 vs. 8718 pg/mL ± 4872; p < 0.01, Figure 2F) were significantly lower in the HF + MO group compared to the HF group.”
Quoted verbatim from Moringa oleifera Improves MAFLD by Inducing Epigenetic Modifications.. - Study
- animal · not in humans
- Duration
- 8 weeks
- Dose
- 150 uL of 62.5 mg/mL extract daily by orogastric cannula, calculated as 290 mg/kg
- Population
- Male C57BL/6J mice fed a high-fat diet with high-sugar drinking water for 16 weeks (NASH model); extract given for the final 8 weeks, compared with untreated high-fat-diet mice
Moringa oleifera Improves MAFLD by Inducing Epigenetic Modifications.2022PMID:36296907Permalink