Papers/PMID:35774540
Efficacy of Glutamine in Treating Severe Acute Pancreatitis: A Systematic Review and Meta-Analysis.
Frontiers in nutrition2022The record
6 findings · 1 compound · 6 endpoints
What it reported
How to read these marksWhat moved
6 findings
L-glutamine — decreases interleukin-6 concentration
LikelyGrade B, Likely. Human evidence with one recorded weakness, or capped at B by its design or by unread numbers.Findingreplicated ×2“The results indicated that Gln supplementation effectively reduced IL-6 levels (SMD = −1.23, 95% CI: −1.68 to −0.78, P < 0.00001; Figure 17).”
Quoted verbatim from Efficacy of Glutamine in Treating Severe Acute Pancreatitis: A Systematic Review and Meta-Analysis.. - Study
- meta-analysis
- Population
- Severe acute pancreatitis patients, pooled across parenteral and enteral glutamine-supplemented nutrition trials
Effect -1.23 standardised mean difference, 95% CI -1.68 to -0.78
Efficacy of Glutamine in Treating Severe Acute Pancreatitis: A Systematic Review and Meta-Analysis.2022PMID:35774540Permalink
L-glutamine — decreases aspartate aminotransferase
LikelyGrade B, Likely. Human evidence with one recorded weakness, or capped at B by its design or by unread numbers.Finding“The meta-analysis results showed that Gln supplementation was more effective in reducing AST level (MD = −21.45, 95% CI: −34.74 to −8.16, P = 0.002; Figure 7).”
Quoted verbatim from Efficacy of Glutamine in Treating Severe Acute Pancreatitis: A Systematic Review and Meta-Analysis.. - Study
- meta-analysis
- Population
- Severe acute pancreatitis patients, pooled across parenteral and enteral glutamine-supplemented nutrition trials
Effect -21.45 mean difference, 95% CI -34.74 to -8.16
Efficacy of Glutamine in Treating Severe Acute Pancreatitis: A Systematic Review and Meta-Analysis.2022PMID:35774540Permalink
L-glutamine — decreases intensive care unit length of stay
LikelyGrade B, Likely. Human evidence with one recorded weakness, or capped at B by its design or by unread numbers.Finding“The pooled results indicated that Gln supplementation was associated with a significantly shorter ICU hospital stay (SMD = −0.93, 95% CI: −1.83 to −0.04, P = 0.04; Figure 6).”
Quoted verbatim from Efficacy of Glutamine in Treating Severe Acute Pancreatitis: A Systematic Review and Meta-Analysis.. - Study
- meta-analysis
- Population
- Severe acute pancreatitis patients, pooled across parenteral and enteral glutamine-supplemented nutrition trials
Effect -0.93 standardised mean difference, 95% CI -1.83 to -0.04
Efficacy of Glutamine in Treating Severe Acute Pancreatitis: A Systematic Review and Meta-Analysis.2022PMID:35774540Permalink
L-glutamine — decreases hospital length of stay
LikelyGrade B, Likely. Human evidence with one recorded weakness, or capped at B by its design or by unread numbers.Findingreplicated ×2“The pooled results showed that Gln supplementation significantly reduced the total length of hospital stay (MD = −3.41, 95% CI: −4.93 to −1.88, P < 0.0001; Figure 7).”
Quoted verbatim from Efficacy of Glutamine in Treating Severe Acute Pancreatitis: A Systematic Review and Meta-Analysis.. - Study
- meta-analysis
- Population
- Severe acute pancreatitis patients, pooled across parenteral and enteral glutamine-supplemented nutrition trials
Effect -3.41 mean difference, 95% CI -4.93 to -1.88
Efficacy of Glutamine in Treating Severe Acute Pancreatitis: A Systematic Review and Meta-Analysis.2022PMID:35774540Permalink
L-glutamine — decreases alanine aminotransferase
LikelyGrade B, Likely. Human evidence with one recorded weakness, or capped at B by its design or by unread numbers.Finding“We selected a random-effects model, and the pooled estimates suggested that Gln supplementation significantly reduced ALT level (MD = −13.73, 95% CI: −16.40 to −11.07, P < 0.00001; Figure 11).”
Quoted verbatim from Efficacy of Glutamine in Treating Severe Acute Pancreatitis: A Systematic Review and Meta-Analysis.. - Study
- meta-analysis
- Population
- Severe acute pancreatitis patients, pooled across parenteral and enteral glutamine-supplemented nutrition trials
Effect -13.73 mean difference, 95% CI -16.4 to -11.07
Efficacy of Glutamine in Treating Severe Acute Pancreatitis: A Systematic Review and Meta-Analysis.2022PMID:35774540Permalink
L-glutamine — decreases tumour necrosis factor alpha concentration
LikelyGrade B, Likely. Human evidence with one recorded weakness, or capped at B by its design or by unread numbers.Findingreplicated ×1“The combined results showed that nutritional supplementation with Gln was effective in reducing TNF-α levels (SMD = −2.47, 95% CI: −3.27 to −1.66, P < 0.00001; Figure 19).”
Quoted verbatim from Efficacy of Glutamine in Treating Severe Acute Pancreatitis: A Systematic Review and Meta-Analysis.. - Study
- meta-analysis
- Population
- Severe acute pancreatitis patients, pooled across parenteral and enteral glutamine-supplemented nutrition trials
Effect -2.47 standardised mean difference, 95% CI -3.27 to -1.66
Efficacy of Glutamine in Treating Severe Acute Pancreatitis: A Systematic Review and Meta-Analysis.2022PMID:35774540Permalink