Papers/PMID:35016033
Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses.
Molecular cell2022The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
L-citrulline — binds JAK2
SpeculativeGrade F, Speculative. Mechanistic inference, no evidence found, or evidence weakened below D.Hypothesis“Reciprocally, increased citrulline directly binds to JAK2 and inhibits JAK2-STAT1 signaling.”
Quoted verbatim from Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses.. - Study
- mechanistic · not in humans
- Population
- macrophages
Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses.2022PMID:35016033Permalink