Papers/PMID:34290409
SAR1B senses leucine levels to regulate mTORC1 signalling.
Nature2021The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
L-leucine — binds SAR1B
SpeculativeGrade F, Speculative. Mechanistic inference, no evidence found, or evidence weakened below D.Finding“In conditions of leucine sufficiency, SAR1B binds to leucine, undergoes a conformational change and dissociates from GATOR2, which results in mTORC1 activation.”
Quoted verbatim from SAR1B senses leucine levels to regulate mTORC1 signalling.. - Study
- in vitro · not in humans
- Population
- cultured cells, biochemical/structural signalling assay
SAR1B senses leucine levels to regulate mTORC1 signalling.2021PMID:34290409Permalink