L-leucine/Finding
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A single claim from the graph, with the grade computed from its study, the sentence it was drawn from, and the paper. This address does not change.
Binds SAR1B
SpeculativeGrade F, Speculative. Mechanistic inference, no evidence found, or evidence weakened below D.Finding“In conditions of leucine sufficiency, SAR1B binds to leucine, undergoes a conformational change and dissociates from GATOR2, which results in mTORC1 activation.”
Quoted verbatim from SAR1B senses leucine levels to regulate mTORC1 signalling.. - Study
- in vitro · not in humans
- Population
- cultured cells, biochemical/structural signalling assay
SAR1B senses leucine levels to regulate mTORC1 signalling.2021PMID:34290409Permalink
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To cite this finding: https://catalystproject.ai/e/01M3J8BT3NCMHBJ46E4HBZDPBM