Papers/PMID:34204220
Astaxanthin Protects Dendritic Cells from Lipopolysaccharide-Induced Immune Dysfunction.
Marine drugs2021The record
4 findings · 1 compound · 4 endpoints
What it reported
How to read these marksWhat moved
4 findings
astaxanthin — decreases interleukin-6 concentration
PreliminaryGrade D, Preliminary. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1“The results showed that administration of astaxanthin significantly decreased the production of TNF-α, IL-6, and IL-10.”
Quoted verbatim from Astaxanthin Protects Dendritic Cells from Lipopolysaccharide-Induced Immune Dysfunction.. - Study
- animal · not in humans
- Population
- LPS-challenged C57BL/6 mice, serum cytokines measured by ELISA 4 h after LPS injection
Astaxanthin Protects Dendritic Cells from Lipopolysaccharide-Induced Immune Dysfunction.2021PMID:34204220Permalink
astaxanthin — activates NFE2L2
PreliminaryGrade D, Preliminary. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“As shown in Figure 8A–D, treatment of LPS-induced DCs with astaxanthin, HO-1, and Nrf2 were significantly upregulated, compared with the LPS-only group.”
Quoted verbatim from Astaxanthin Protects Dendritic Cells from Lipopolysaccharide-Induced Immune Dysfunction.. - Study
- in vitro · not in humans
- Population
- LPS-induced murine bone-marrow-derived dendritic cells
Astaxanthin Protects Dendritic Cells from Lipopolysaccharide-Induced Immune Dysfunction.2021PMID:34204220Permalink
astaxanthin — inhibits CCR7
PreliminaryGrade D, Preliminary. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“With LPS treatment alone, CCR7 expression was significantly increased, whereas they remarkably declined after the treatment of astaxanthin.”
Quoted verbatim from Astaxanthin Protects Dendritic Cells from Lipopolysaccharide-Induced Immune Dysfunction.. - Study
- in vitro · not in humans
- Population
- LPS-induced murine bone-marrow-derived dendritic cells
Astaxanthin Protects Dendritic Cells from Lipopolysaccharide-Induced Immune Dysfunction.2021PMID:34204220Permalink
astaxanthin — decreases tumour necrosis factor alpha concentration
SpeculativeGrade F, Speculative. Mechanistic inference, no evidence found, or evidence weakened below D.Finding“The results showed that administration of astaxanthin significantly decreased the production of TNF-α, IL-6, and IL-10.”
Quoted verbatim from Astaxanthin Protects Dendritic Cells from Lipopolysaccharide-Induced Immune Dysfunction.. - Study
- animal · not in humans
- Population
- LPS-challenged C57BL/6 mice, serum cytokines measured by ELISA 4 h after LPS injection
Astaxanthin Protects Dendritic Cells from Lipopolysaccharide-Induced Immune Dysfunction.2021PMID:34204220Permalink